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(NeurdyPhagy Lab members are underlined)

Available as Preprint

• #Abrar, F., #Davies, M.C., Kumar, A., Dang, A., Nguyen, Y.T.N., Collins, J., Caron, N., Choudhary J.S., Sanders, S.S., Collins, M.O., Hayden, M.R., Martin, D.D.O. (2023) Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy. Available on BioRxiv

  #Equal Contribution

Available on Pubmed

• Jeong, H., Gonzalez-Fernandez, E., Crawley, I., Hwang, J., Martin, D.D.O., Bamji, S.X., Kim, J., Kang, S.H., Thomas, G.M. (2024) Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9. eLife Reviewed Preprint

• Napier, M., Kumar, A., Szulist, N., Martin, D.D.O., and Scott, A.L. (2024) P2X7 Expression Patterns in the Developing Fmr1-Knockout Mouse Hippocampus. Hippocampus. Available online https://doi.org/10.1002/hipo.23634

• Wlodarczyk, J., Bhattacharyya, R., Dore, K., Ho, G.P.H., Martin, D.D.O., Mejias, R., Hochrainer, K. (2024) Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders. Journal of Neuroscience. 44 (40) e1225242024; doi.org/10.1523/JNEUROSCI.1225-24.2024

• Ramzan, F., Kumar, A., Abrar, F., Gray, R.V., Campbell, Z.E., Liao, L.M., Dang, A., Akanni, O., Guyn, C.M., Martin, D.D.O. (2024) Fatty links between multisystem proteinopathy and Small VCP-Interacting Protein. Cell Death Discovery.

• Alshehabi, Y. and Martin, D.D.O. (2024) Protective proteolysis in Huntington Disease: Unraveling the role of post-translational myristoylation of huntingtin. Journal of Huntington Disease.  DOI: 10.3233/JHD-240028

• Martin, D.D.O. & Sanders, S.S. (2024) Let’s get fat: Emergence of targeting S-acylation in Huntington Disease as a novel therapeutic. https://doi.org/10.1042/BST20231290 In Press. Biochemical Society Transactions

• Caron, N.S., Aly, A.E., Black, H.F., Martin, D.D.O., Schmidt, M.E., Ko, Y., Anderson, C., Casal, L.L., Anderson, L.M., Rahavi, R.S.M., Reid, G.S.D., Oda, M.N., Stanimirovic, D., Abulrob, A., McBride, J.L., Leavitt, B.R., Hayden, M.R. (2024) Apolipoprotein A-I nanodiscs as vehicles for delivering HTT-targeted antisense oligonucleotides to the central nervous system for Huntington disease. Journal of Controlled Release PMID: 38215984

• Aly, A.E., Caron, N.S., Black, H.F., Schmidt, M.E., Anderson, C., Ko, S., Baddeley, H.J.E., Anderson, L., Casal, L.L., Rahavi, R.S.M., Martin, D.D.O., Hayden, M.R.(2023) Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodiscs. Journal of Controlled Release 360:913-927. PMID:37468110

• Ramzan, F., Abrar, F., Mishra, G.G., Liao, L.M., Martin, D.D.O.(2023) Lost in Traffic: Consequences of Altered Palmitoylation in Neurodegeneration. Frontiers in Physiology 14(846) PMID:37324388

• Lemarié, F.L., Sanders, S.S., Nguyen, Y.T.N., Martin,D.D.O.#, Hayden, M.R.# (2023) Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage. Frontiers in Physiology doi: 10.3389/fphys.2023.1086112

  #Equal Contribution

• Liao, L.M.Q., Gray, R.A.V., Martin, D.D.O. (2021) Optimized delivery of alkyne fatty acids for the detection of fatty acylation using Click Chemistry. J. Vis. Exp. e62107(170). PMID: 33900285

  • Open Access

• Martin, D.D.O., Kanuparthi. P., Holland, S.M., Sanders, S.S., Jeoung, H., Einarson, M., Jacobson, M., Thomas, G.M. (2018) Identification of novel inhibitors of DLK palmitoylation by High Content Screening. Scientific Reports 9(3632). PMID: 30842471. BioRxiv

• Martin, D.D.O., Schmidt, M.E., Nguyen, Y.T., Lazic, N., Hayden, M.R. (2018) Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance. FASEB J 33(3): 3190-3197. PMID: 30823259. BioRxiv

  • Highlighted by Stem Cell Technologies blog Science in the City

• Martin, D.D.O., Kay, C., Collins, J., Nguyen, Y.T., Slama, R. and Hayden, M.R. (2018) A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease. Sci Rep 8(1):8096. PMID: 29802276. BioRxiv

• Ehrnhoefer, D.E., Martin, D.D.O., Qiu, X., Ladha, S., Skotte, N., Nguyen, Y.T.N., Vaid, K., Engemann, S., Franciosi, S., Hayden, M.N. (2017) Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington Disease. Acta Neuropathologica Communications 6(1):16 PMID: 29510748. BioRxiv

  • Highlighted on multiple news sites, including EurekAlert, Neuroscience News

• Martin, D.D.O. and Hayden, M.R. (2017) Role of Repeats in Protein Clearance. 545, 33–34 doi:10.1038/nature22489 Nature PMID: 28445458

• Sanders, S.S.*, Martin, D.D.O.*, Butland, S., Lavallée-Adam, M., Calzolari, D., Kay, C., Yates, J.R., Hayden, M.R. (2015) Assembly of the mammalian palmitoylome indicates a pivotal role for palmitoylation in neurodegeneration and cancer. 11(8): e1004405. PLoS Comp Bio PMID: 26275289

  • *contributed equally

• Martin, D.D.O. & Hayden, M.R. (2015) Post-translational myristoylation at the cross roads of cell death and autophagy and neurodegeneration. 43(2); 229-234. Biochem Soc Trans PMID: 25849922

• Wong, B.K.Y.*, Ehrnhoefer, D.E.*, Graham, R.K., Martin, D.D.O., Uribe, V., Ladha, S., Stanek, L.M, Franciosi, S., Qiu, X., Deng, Y., Kovalik, V., Zhang, W., Pouladi, M.A., Shihabuddin, L., Hayden, M.R. (2015) Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. (*co-first authors) Neurobiology of Disease (76):24-36. PMID: 25583186

• Martin, D.D.O., Ladha, S., Ehrnhoefer, D.E., Hayden, M.R. (2015) Autophagy in Huntington Disease and Huntingtin in Autophagy. Trends in Neuroscience 38(1):26-35 PMID: 25282404

  • Chosen for the cover of the January 1, 2015 issue

• Martin, D.D.O., Heit,R.J., Yap, M.C., Davidson, M.W., Hayden, M.R, Berthiaume, L.G. (2014) Identification of a posttranslationally myristoylated autophagy inducing domain released by caspase cleavage of Huntingtin. Hum Mol Genet 23(12):3166-3179 PMID: 24459296

  • Chosen for the cover of the June 15, 2014 issue

• Martin, D.D.O.,  Ahpin, C.Y., Heit, R.J., Perinpanayagam, M.A., Yap, M.C., Veldhoen, R.A., Goping, I.S., Berthiaume, L.G. (2012) Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKCɛ; a case study. FASEB J. 26(1):13-28 PMID: 21965604

• Martin, D.D.O.*, Beauchamp, E.*, Berthiaume, L.G. (2011) Post-translational myristoylation: fat matters in cellular life and death (*denotes co-first authors). Biochimie 93(1):18-31. PMID: 21056615

• Yap, Y.C.*, Kostiuk, M.A.*, Martin, D.D.O., Perinpanayagam, M.A., Hak, P.G., Siddam, A., Majjigapum, J.R., Rajaiah, G., Keller, B.O., Prescher, J.A., Wu, P., Bertozzi, C.R., Falck, J.R., Berthiaume, L.G. (2010) Rapid and selective detection of fatty acylated proteins using omega- alkynyl-fatty acids and click chemistry. J Lipid Res. 51(6):1566-80 (*co-first authors) PMID:20028662 

• Martin, D.D.O., Vilas, G.L., Prescher, J.A., Rajaiah, G., Falck, J.R., Bertozzi, C.R., Berthiaume, L.G. (2008) Rapid detection, discovery and identification of post-translationally myristoylated proteins during apoptosis using a bioorthogonal azidomyristate analogue. FASEB J. 22(3):797-806 PMID: 17932026